Progression and Natural History of Nonalcoholic Fatty Liver Disease in Adults

Andrea Marengo; Ramy Ibrahim Kamal Jouness; Elisabetta Bugianesi

doi:10.1016/j.cld.2015.10.010

Progression and Natural History of Nonalcoholic Fatty Liver Disease in Adults

Clin Liver Dis. 2016 May;20(2):313-24. doi: 10.1016/j.cld.2015.10.010. Epub 2015 Dec 24.

Authors

Andrea Marengo¹, Ramy Ibrahim Kamal Jouness¹, Elisabetta Bugianesi²

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Medical Sciences, A.O. Città della Salute e della Scienza di Torino, University of Turin, Corso Bramante 88, Turin I-10126, Italy.
² Division of Gastroenterology and Hepatology, Department of Medical Sciences, A.O. Città della Salute e della Scienza di Torino, University of Turin, Corso Bramante 88, Turin I-10126, Italy. Electronic address: elisabetta.bugianesi@unito.it.

PMID: 27063271
DOI: 10.1016/j.cld.2015.10.010

Abstract

Liver-related mortality is the third cause of death in patients with nonalcoholic fatty liver disease, but the long-term prognosis basically depends on the presence and severity of liver damage. Thus, life expectancy in patients with simple steatosis is not different from the general population, but liver-related mortality is significantly higher in patients with nonalcoholic steatohepatitis (NASH), particularly in those with advanced fibrosis. Progression of liver disease is observed in up to one-third of patients with NASH. The long-term hepatic prognosis mostly depends on the histologic stage at initial liver biopsy, but multiple risk factors may concur.

Keywords: Cirrhosis; Hepatocellular carcinoma; Obesity; Steatohepatitis; Type 2 diabetes.

Publication types

Review

MeSH terms

Carcinoma, Hepatocellular / epidemiology*
Carcinoma, Hepatocellular / etiology
Disease Progression*
Humans
Ideal Body Weight
Incidence
Liver Cirrhosis / epidemiology*
Liver Cirrhosis / etiology
Liver Neoplasms / epidemiology*
Liver Neoplasms / etiology
Non-alcoholic Fatty Liver Disease / complications
Non-alcoholic Fatty Liver Disease / epidemiology*
Non-alcoholic Fatty Liver Disease / genetics
Non-alcoholic Fatty Liver Disease / mortality
Risk Factors