A Janus Mucoadhesive and Omniphobic Device for Gastrointestinal Retention

Young-Ah Lucy Lee; Shiyi Zhang; Jiaqi Lin; Robert Langer; Giovanni Traverso

doi:10.1002/adhm.201501036

A Janus Mucoadhesive and Omniphobic Device for Gastrointestinal Retention

Adv Healthc Mater. 2016 May;5(10):1141-6. doi: 10.1002/adhm.201501036. Epub 2016 Apr 6.

Authors

Young-Ah Lucy Lee¹, Shiyi Zhang¹, Jiaqi Lin¹, Robert Langer^{1

2}, Giovanni Traverso^{1

3}

Affiliations

¹ Department of Chemical Engineering and Koch Institute for Integrative Cancer, Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
² Harvard-MIT Division of Health Sciences and Technology, Institute of Technology, Massachusetts, Cambridge, MA, 02139, USA.
³ Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Abstract

A novel Janus device with omniphobic and mucoadhesive sides that exhibit the unique capacity for antifouling and extended gastrointestinal retention is fabricated. This system enables repulsion of the food and fluid stream by the luminal-facing omniphobic side and allows attachment to the gastrointestinal mucosa by the mucoadhesive side.

Keywords: bioinspired; gastrointestinal retention; janus; mucoadhesive; omniphobic.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adhesives / metabolism*
Animals
Drug Delivery Systems / methods
Gastrointestinal Tract / metabolism*
Humans
Mucous Membrane / metabolism*
Swine
Water / metabolism

Substances

Adhesives
Water

Abstract

Publication types

MeSH terms

Substances

Grants and funding