Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease

J Physiol. 2016 Jul 15;594(14):3853-75. doi: 10.1113/JP271840. Epub 2016 Jun 17.

Abstract

The nervous system and cardiovascular system develop in concert and are functionally interconnected in both health and disease. This white paper focuses on the cellular and molecular mechanisms that underlie neural-cardiac interactions during development, during normal physiological function in the mature system, and during pathological remodelling in cardiovascular disease. The content on each subject was contributed by experts, and we hope that this will provide a useful resource for newcomers to neurocardiology as well as aficionados.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Heart / innervation*
  • Heart / physiology*
  • Heart / physiopathology
  • Heart Diseases / physiopathology*
  • Humans
  • Neurotransmitter Agents / physiology
  • Synaptic Transmission

Substances

  • Neurotransmitter Agents