Surgical Sutures with Porous Sheaths for the Sustained Release of Growth Factors

Jianhua Li; Stephen W Linderman; Chunlei Zhu; Hong Liu; Stavros Thomopoulos; Younan Xia

doi:10.1002/adma.201506242

Surgical Sutures with Porous Sheaths for the Sustained Release of Growth Factors

Adv Mater. 2016 Jun;28(23):4620-4. doi: 10.1002/adma.201506242. Epub 2016 Apr 5.

Authors

Jianhua Li^{1

2}, Stephen W Linderman^{3

4}, Chunlei Zhu¹, Hong Liu², Stavros Thomopoulos^{5

6}, Younan Xia^{1

7

8}

Affiliations

¹ The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
² State Key Laboratory of Crystal Materials, Shandong University, Jinan, Shandong, 250100, P. R. China.
³ Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
⁴ Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, 63130, USA.
⁵ Department of Orthopedic Surgery, Columbia University, New York, NY, 10032, USA.
⁶ Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
⁷ School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
⁸ School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Abstract

Surgical sutures with highly porous sheaths are developed using a swelling and freeze-drying procedure without compromising their mechanical properties. The modified sutures show a high capacity for loading biofactors and are able to release the loaded biofactors in a sustained manner.

Keywords: drug delivery; sustained release; suture; tendon repair.

MeSH terms

Cell Survival / drug effects
Delayed-Action Preparations*
Drug Liberation*
Humans
Intercellular Signaling Peptides and Proteins / administration & dosage*
Intercellular Signaling Peptides and Proteins / analysis*
Intercellular Signaling Peptides and Proteins / chemistry
Intercellular Signaling Peptides and Proteins / pharmacology
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / drug effects
Porosity*
Sutures*

Substances

Delayed-Action Preparations
Intercellular Signaling Peptides and Proteins

Abstract

MeSH terms

Substances

Grants and funding