CSR-1 Slices a Balance

Ruby Yu; Danesh Moazed

doi:10.1016/j.cell.2016.03.019

CSR-1 Slices a Balance

Cell. 2016 Apr 7;165(2):267-9. doi: 10.1016/j.cell.2016.03.019.

Authors

Ruby Yu¹, Danesh Moazed²

Affiliations

¹ Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
² Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: danesh@hms.harvard.edu.

PMID: 27058659
DOI: 10.1016/j.cell.2016.03.019

Abstract

CSR-1 is a germline-expressed C. elegans Argonaute protein essential for viability. In this issue of Cell, Gerson-Gurwitz et al. now demonstrate a role for CSR-1 and its slicer activity in downregulating the levels of maternally deposited mRNAs to fine-tune the expression of proteins with critical roles in embryonic cell divisions.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Argonaute Proteins / metabolism
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / metabolism*
Germ Cells / metabolism

Substances

Argonaute Proteins
Caenorhabditis elegans Proteins

Grants and funding

Howard Hughes Medical Institute/United States