Non-invasive glioblastoma immunoprofiling by printed peptide arrays

Oncoimmunology. 2015 Aug 12;5(2):e1069941. doi: 10.1080/2162402X.2015.1069941. eCollection 2016 Feb.

Abstract

Immune monitoring assays for patient stratification and treatment efficacy in clinical trials are in demand. We have recently described a cost-effective non-invasive assay to determine the immune status of glioblastoma patients. Profiling antitumor serum antibodies by customized printed peptide arrays identified response against a tenascin-C (TNC) peptide as a robust prognostic biomarker.

Keywords: Antibodies; TNC; glioblastoma; long-term survival; non-invasive; biomarker; serum.