Biointerface by Cell Growth on Graphene Oxide Doped Bacterial Cellulose/Poly(3,4-ethylenedioxythiophene) Nanofibers

Chuntao Chen; Ting Zhang; Qi Zhang; Xiao Chen; Chunlin Zhu; Yunhua Xu; Jiazhi Yang; Jian Liu; Dongping Sun

doi:10.1021/acsami.6b01243

Biointerface by Cell Growth on Graphene Oxide Doped Bacterial Cellulose/Poly(3,4-ethylenedioxythiophene) Nanofibers

ACS Appl Mater Interfaces. 2016 Apr 27;8(16):10183-92. doi: 10.1021/acsami.6b01243. Epub 2016 Apr 14.

Authors

Chuntao Chen¹, Ting Zhang², Qi Zhang^{3

2}, Xiao Chen¹, Chunlin Zhu¹, Yunhua Xu^{1

4}, Jiazhi Yang¹, Jian Liu², Dongping Sun¹

Affiliations

¹ Institute of Chemicobiology and Functional Materials, School of Chemical Engineering, Nanjing University of Science and Technology , 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province, China.
² Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University , 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, Jiangsu Province, China.
³ School of Radiation Medicine and Protection and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University , 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, Jiangsu Province, China.
⁴ Lianyungang Normal College , Lianyungang, Jiangsu, China.

PMID: 27054801
DOI: 10.1021/acsami.6b01243

Abstract

Highly biocompatible advanced materials with excellent electroactivity are increasingly meaningful to biointerfaces and the development of biomedicine. Herein, bacterial cellulose/poly(3,4-ethylene dioxythiophene)/graphene oxide (BC/PEDOT/GO) composite nanofibers were synthesized through the in situ interfacial polymerization of PEDOT with the doping of GO. The abundant free carboxyl and hydroxy groups offer the BC/PEDOT/GO film active functional groups for surface modification. We demonstrate the use of this composite nanofiber for the electrical stimulation of PC12 neural cells as this resultant nanofiber scaffold could closely mimic the structure of the native extracellular matrix (ECM) with a promoting cell orientation and differentiation after electrical stimulation of PC12 cells. It is expected that this biocompatible BC/PEDOT/GO material will find potential applications in biological and regenerative medicine.

Keywords: bacterial cellulose nanofibers; biointerface; electrical stimulus; graphene oxide; poly(3,4-ethylenedioxythiophene).

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Bridged Bicyclo Compounds, Heterocyclic
Cell Proliferation
Cellulose
Graphite
Nanofibers*
Oxides
PC12 Cells
Polymers
Rats

Substances

Bridged Bicyclo Compounds, Heterocyclic
Oxides
Polymers
poly(3,4-ethylene dioxythiophene)
Graphite
Cellulose