Abacavir-induced liver toxicity

Braz J Infect Dis. 2016 Sep-Oct;20(5):502-4. doi: 10.1016/j.bjid.2016.03.002. Epub 2016 Apr 4.

Abstract

Abacavir-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients. Herein, we report one case of abnormal liver function tests occurring in a young HLA B*5701-negative woman on a stable nevirapine-based regimen with no history of liver problems or alcohol abuse after switching to abacavir from tenofovir. We also investigated the reasons for abacavir discontinuation in a cohort of patients treated with abacavir-lamivudine-nevirapine.

Keywords: Abacavir; HIV; Liver toxicity.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Anti-HIV Agents / adverse effects*
  • Antiretroviral Therapy, Highly Active / adverse effects*
  • Chemical and Drug Induced Liver Injury / etiology*
  • Dideoxynucleosides / adverse effects*
  • Female
  • HIV Infections / drug therapy
  • HLA-B Antigens / immunology
  • Humans
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome

Substances

  • Anti-HIV Agents
  • Dideoxynucleosides
  • HLA-B Antigens
  • HLA-B*57:01 antigen
  • abacavir