Sesquiterpenoids from the seeds of Sarcandra glabra and the potential anti-inflammatory effects

Fitoterapia. 2016 Jun:111:7-11. doi: 10.1016/j.fitote.2016.03.020. Epub 2016 Apr 2.

Abstract

Five new sesquiterpenoids, including two linderanes (1-2) and three eudesmanes (3-5) were isolated from the seeds of Sarcandra glabra. Their structures and relative configurations were established by spectroscopic data analysis. 1 was a rare linderane derivative having an 18-membered triester ring which is a common characteristic in linderane dimers. Compounds 1-5 were investigated for their inhibitory effects on NO production in LPS-induced macrophages and 1 showed moderate bioactivity.

Keywords: Eudesmanes; Linderanes; Nitric oxide; Sarcandra glabra; Sesquiterpenoids.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / isolation & purification
  • Drugs, Chinese Herbal / chemistry
  • Furans / chemistry
  • Furans / isolation & purification
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Magnoliopsida / chemistry*
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • RAW 264.7 Cells
  • Seeds / chemistry*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes, Eudesmane / chemistry
  • Sesquiterpenes, Eudesmane / isolation & purification

Substances

  • Anti-Inflammatory Agents
  • Drugs, Chinese Herbal
  • Furans
  • Sesquiterpenes
  • Sesquiterpenes, Eudesmane
  • linderane
  • Nitric Oxide
  • eudesmane