Abstract
Five new sesquiterpenoids, including two linderanes (1-2) and three eudesmanes (3-5) were isolated from the seeds of Sarcandra glabra. Their structures and relative configurations were established by spectroscopic data analysis. 1 was a rare linderane derivative having an 18-membered triester ring which is a common characteristic in linderane dimers. Compounds 1-5 were investigated for their inhibitory effects on NO production in LPS-induced macrophages and 1 showed moderate bioactivity.
Keywords:
Eudesmanes; Linderanes; Nitric oxide; Sarcandra glabra; Sesquiterpenoids.
Copyright © 2016 Elsevier B.V. All rights reserved.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / isolation & purification
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Drugs, Chinese Herbal / chemistry
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Furans / chemistry
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Furans / isolation & purification
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Macrophages / drug effects
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Macrophages / metabolism
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Magnoliopsida / chemistry*
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Mice
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Molecular Structure
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Nitric Oxide / metabolism
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RAW 264.7 Cells
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Seeds / chemistry*
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes, Eudesmane / chemistry
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Sesquiterpenes, Eudesmane / isolation & purification
Substances
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Anti-Inflammatory Agents
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Drugs, Chinese Herbal
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Furans
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Sesquiterpenes
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Sesquiterpenes, Eudesmane
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linderane
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Nitric Oxide
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eudesmane