Bone loss in chronic kidney disease: Quantity or quality?

Cai-Mei Zheng; Jin-Quan Zheng; Chia-Chao Wu; Chien-Lin Lu; Jia-Fwu Shyu; Hsu Yung-Ho; Mei-Yi Wu; I-Jen Chiu; Yuan-Hung Wang; Yuh-Feng Lin; Kuo-Cheng Lu

doi:10.1016/j.bone.2016.03.017

Bone loss in chronic kidney disease: Quantity or quality?

Bone. 2016 Jun:87:57-70. doi: 10.1016/j.bone.2016.03.017. Epub 2016 Apr 2.

Authors

Cai-Mei Zheng¹, Jin-Quan Zheng², Chia-Chao Wu³, Chien-Lin Lu⁴, Jia-Fwu Shyu⁵, Hsu Yung-Ho¹, Mei-Yi Wu⁶, I-Jen Chiu⁷, Yuan-Hung Wang⁸, Yuh-Feng Lin¹, Kuo-Cheng Lu⁹

Affiliations

¹ Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan.
² Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan; Division of Pulmonary and Critical Care, Department of Critical Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taiwan.
³ Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
⁴ Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan.
⁵ Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
⁶ Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan.
⁷ Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taiwan.
⁸ Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan; Department of Medical Research, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
⁹ Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan; Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Division of Nephrology, Department of Medicine, Cardinal-Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City,Taiwan. Electronic address: kuochenglu@gmail.com.

PMID: 27049042
DOI: 10.1016/j.bone.2016.03.017

Abstract

Chronic kidney disease (CKD) patients experience bone loss and fracture because of a specific CKD-related systemic disorder known as CKD-mineral bone disorder (CKD-MBD). The bone turnover, mineralization, and volume (TMV) system describes the morphological bone lesions in renal osteodystrophy related to CKD-MBD. Bone turnover and bone volume are defined as high, normal, or low, and bone mineralization is classified as normal or abnormal. All types of bone histology related to TMV are responsible for both bone quantity and bone quality losses in CKD patients. This review focuses on current bone quantity and bone quality losses in CKD patients and finally discusses potential therapeutic measures.

Keywords: Bone quantity and bone quality losses; Bone remodeling; Chronic kidney disease–mineral bone disorder (CKD–MBD); Vitamin D therapy.

Publication types

Review

MeSH terms

Animals
Biomarkers / metabolism
Bone Density
Bone Remodeling
Bone Resorption / complications*
Bone Resorption / pathology*
Bone Resorption / physiopathology
Bone Resorption / therapy
Cellular Microenvironment
Humans
Renal Insufficiency, Chronic / complications*
Renal Insufficiency, Chronic / pathology*
Renal Insufficiency, Chronic / physiopathology
Renal Insufficiency, Chronic / therapy

Substances

Biomarkers