Abstract
A series of rigid phenylene vinylene macrocycles and phenylene ethynylene macrocycles with various substituents have been investigated as transmembrane ion channels. The length and polarity of the substituents have a significant effect on the ion channel formation and the mass transport efficiency. Macrocycles with strong aggregation facilitate ion passage across lipid bilayers.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkynes / chemistry*
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Arylsulfonates / chemistry
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Facilitated Diffusion
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Fluoresceins / chemistry
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Fluorescent Dyes / chemistry
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Hydrogen-Ion Concentration
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Ionophores / chemistry*
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Macrocyclic Compounds / chemistry*
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Molecular Structure
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Sodium Chloride / chemistry
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Stilbenes / chemistry*
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Unilamellar Liposomes / chemistry
Substances
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Alkynes
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Arylsulfonates
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Fluoresceins
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Fluorescent Dyes
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Ionophores
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Macrocyclic Compounds
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Stilbenes
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Unilamellar Liposomes
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Sodium Chloride
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pyranine
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fluorexon