Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration

Elham Masoudi; João Ribas; Gaurav Kaushik; Jeroen Leijten; Ali Khademhosseini

doi:10.1007/s40778-016-0034-8

Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration

Curr Stem Cell Rep. 2016 Mar;2(1):33-42. doi: 10.1007/s40778-016-0034-8. Epub 2016 Feb 13.

Authors

Elham Masoudi^#^{1

2}, João Ribas^#^{1

2

3}, Gaurav Kaushik^{1

2}, Jeroen Leijten^{1

2}, Ali Khademhosseini^{1

2

4

5

6}

Affiliations

¹ Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
³ Doctoral Program in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal.
⁴ Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
⁵ Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
⁶ Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia.

^# Contributed equally.

Abstract

Platelet rich blood derivatives have been widely used in different fields of medicine and stem cell based tissue engineering. They represent natural cocktails of autologous growth factor, which could provide an alternative for recombinant protein based approaches. Platelet rich blood derivatives, such as platelet rich plasma, have consistently shown to potentiate stem cell proliferation, migration, and differentiation. Here, we review the spectrum of platelet rich blood derivatives, discuss their current applications in tissue engineering and regenerative medicine, reflect on their effect on stem cells, and highlight current translational challenges.

Keywords: autologous growth factors; blood derivatives; cell proliferation; platelet rich plasma; stem cell differentiation; stem cells.

Abstract

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