Abstract
Curvularia sp. IFB-Z10, a white croaker-associated fungus, generates a skeletally unprecedented indolizine alkaloid named curindolizine (1), which displays an anti-inflammatory action in lipopolyssacharide (LPS)-induced RAW 264.7 macrophages with an IC50 value of 5.31 ± 0.21 μM. The enzymatic transformation test demonstrated that the unique curindolizine architecture was most likely produced by the regiospecific in-cell Michael addition reaction between pyrrole alkaloids, curvulamine, and 3,5-dimethylindolizin-8(5H)-one.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Fungi
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Indole Alkaloids
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Indolizines / chemistry*
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Inhibitory Concentration 50
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Lipopolysaccharides / chemistry*
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Pyrroles / chemistry*
Substances
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3,5-dimethylindolizin-8(5H)-one
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Alkaloids
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Indole Alkaloids
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Indolizines
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Lipopolysaccharides
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Pyrroles
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curvulamine