Choroidal metastasis as a presenting manifestation of a lung adenocarcinoma with response to afatinib

M Contreras-Díaz; A Medina-Tapia; G Martínez-Bernal; T Rueda-Rueda; F López-Herrero; F E Molina-Socola; J L Sánchez-Vicente

doi:10.1016/j.oftal.2016.03.002

Choroidal metastasis as a presenting manifestation of a lung adenocarcinoma with response to afatinib

Arch Soc Esp Oftalmol. 2016 Nov;91(11):551-555. doi: 10.1016/j.oftal.2016.03.002. Epub 2016 Apr 1.

[Article in English, Spanish]

Authors

M Contreras-Díaz¹, A Medina-Tapia², G Martínez-Bernal³, T Rueda-Rueda², F López-Herrero², F E Molina-Socola², J L Sánchez-Vicente²

Affiliations

¹ Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address: Mig.contreras@hotmail.com.
² Unidad de Gestión Clínica de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.
³ Unidad de Gestión Clínica de Oncología, Hospital Universitario Virgen del Rocío, Sevilla, España.

PMID: 27046001
DOI: 10.1016/j.oftal.2016.03.002

Abstract

Case report: We present the case of a 55-year-old man with a non-small cell lung adenocarcinoma, who presented with choroidal metastasis. The patient showed a decrease in visual acuity. His evaluation revealed unilateral choroidal metastasis secondary to carcinoma of the lung. The patient received afatinib with complete regression of choroidal metastasis after one year follow-up.

Discussion: Choroidal metastasis may be the initial sign of lung cancer. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours. Afatinib was effective against choroidal metastasis of a lung adenocarcinoma with EFGR mutation.

Keywords: Adenocarcinoma de pulmón; Afatinib; Choroidal metastasis; Choroidal tumours; EFGR mutation; Lung adenocarcinoma; Metástasis coroidea; Mutación EFGR; Tumores coroideos.

MeSH terms

Adenocarcinoma / diagnosis
Adenocarcinoma / drug therapy
Adenocarcinoma / enzymology
Adenocarcinoma / secondary*
Adenocarcinoma of Lung
Afatinib
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use*
Carcinoma, Non-Small-Cell Lung / diagnosis
Carcinoma, Non-Small-Cell Lung / drug therapy
Carcinoma, Non-Small-Cell Lung / enzymology
Carcinoma, Non-Small-Cell Lung / secondary*
Choroid Neoplasms / diagnosis
Choroid Neoplasms / drug therapy
Choroid Neoplasms / enzymology
Choroid Neoplasms / secondary*
ErbB Receptors / antagonists & inhibitors
Humans
Lung Neoplasms / diagnosis*
Lung Neoplasms / drug therapy
Lung Neoplasms / enzymology
Male
Middle Aged
Neoplasm Proteins / antagonists & inhibitors
Protein Kinase Inhibitors / pharmacology
Protein Kinase Inhibitors / therapeutic use*
Quinazolines / pharmacology
Quinazolines / therapeutic use*
Remission Induction
Signal Transduction / drug effects

Substances

Antineoplastic Agents
Neoplasm Proteins
Protein Kinase Inhibitors
Quinazolines
Afatinib
EGFR protein, human
ErbB Receptors