Abstract
This study reports the effects of oral Aloe vera gel powder (AVGP) containing Aloe sterols on skin elasticity and the extracellular matrix in ultraviolet B (UVB)-irradiated hairless mice. Ten-week-old hairless mice were fed diets containing 0.3% AVGP for 8 weeks and irradiated UVB for 6 weeks. Mice treated with AVGP showed significant prevention of the UVB-induced decrease in skin elasticity. To investigate the mechanism underlying this suppression of skin elasticity loss, we measured the expression of matrix metalloproteinase (MMP)-2, -9, and -13. AVGP prevented both the UVB-induced increases in MMPs expressions. Moreover, we investigated hyaluronic acid (HA) content of mice dorsal skin and gene expression of HA synthase-2 (Has2). In the results, AVGP oral administration prevented UVB-induced decreasing in skin HA content and Has2 expression and attenuates the UVB-induced decrease in serum adiponectin, which promotes Has2 expression. These results suggested that AVGP has the ability to prevent the skin photoaging.
Keywords:
Aloe vera; MMP; UVB; extracellular matrix; skin elasticity.
MeSH terms
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Adiponectin / blood
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Adiponectin / genetics
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Administration, Oral
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Aloe / chemistry*
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Animals
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Elasticity / drug effects*
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Elasticity / physiology
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Elasticity / radiation effects
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Extracellular Matrix / drug effects
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Extracellular Matrix / metabolism
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Extracellular Matrix / radiation effects
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Female
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Gels / chemistry
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Gels / pharmacology
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Gene Expression Regulation
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Glucuronosyltransferase / genetics
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Glucuronosyltransferase / metabolism
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Hyaluronan Synthases
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Hyaluronic Acid / biosynthesis
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Matrix Metalloproteinase 13 / genetics
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Matrix Metalloproteinase 13 / metabolism
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Matrix Metalloproteinase 2 / genetics*
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Matrix Metalloproteinase 2 / metabolism
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Matrix Metalloproteinase 9 / genetics
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Matrix Metalloproteinase 9 / metabolism
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Mice
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Mice, Hairless
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Powders
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Skin / drug effects*
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Skin / radiation effects
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Skin Aging / drug effects*
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Skin Aging / radiation effects
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Ultraviolet Rays / adverse effects
Substances
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Adiponectin
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Adipoq protein, mouse
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Gels
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Plant Extracts
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Powders
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Hyaluronic Acid
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Glucuronosyltransferase
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Has2 protein, mouse
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Hyaluronan Synthases
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Matrix Metalloproteinase 13
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Matrix Metalloproteinase 2
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Matrix Metalloproteinase 9