Epidermal growth factor receptor (EGFR) mutations in small cell lung cancers: Two cases and a review of the literature

Lung Cancer. 2016 May:95:65-72. doi: 10.1016/j.lungcan.2016.02.012. Epub 2016 Feb 26.

Abstract

Activating mutations in the epidermal growth factor receptor (EGFR) gene are exceedingly rare in small cell lung cancer (SCLC). We present two cases of SCLC harboring EGFR mutations, one in an 82 year-old male smoker with a combined SCLC and adenocarcinoma with a novel D855H point mutation in exon 21, and the second in a 68 year-old female never smoker with the L858R point mutation in exon 21. The cases, accompanied by a review of the literature, highlight the importance of integration of clinicopathologic considerations and adherence to recently promulgated Guideline recommendations for molecular testing in lung cancer.

Keywords: Adenocarcinoma; EGFR; Guideline; Molecular; Pathology; SCLC.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amino Acid Substitution
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biopsy
  • Codon
  • Combined Modality Therapy
  • DNA Mutational Analysis
  • ErbB Receptors / genetics*
  • Fatal Outcome
  • Female
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / therapy
  • Male
  • Mutation*
  • Positron Emission Tomography Computed Tomography
  • Small Cell Lung Carcinoma / diagnosis
  • Small Cell Lung Carcinoma / genetics*
  • Small Cell Lung Carcinoma / therapy
  • Treatment Outcome

Substances

  • Codon
  • ErbB Receptors