Single-layer MoS2 nanosheet grafted upconversion nanoparticles for near-infrared fluorescence imaging-guided deep tissue cancer phototherapy

Nanoscale. 2016 Apr 21;8(15):7861-5. doi: 10.1039/c6nr00150e.

Abstract

A multifunctional nanostructure is prepared by covalently grafting upconversion nanoparticles (UCNPs) with chitosan functionalized MoS2 (MoS2-CS) and folic acid (FA) and then loading phthalocyanine (ZnPc) on the surface of MoS2, which integrates photodynamic therapy (PDT) with photothermal therapy (PTT) and upconversion luminescence imaging into one system for enhanced antitumor efficiency.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / therapy
  • Cell Line, Tumor
  • Disulfides / chemistry
  • Female
  • Humans
  • Infrared Rays
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / therapeutic use*
  • Mice
  • Mice, Nude
  • Molybdenum / chemistry
  • Nanotechnology
  • Neoplasms / diagnostic imaging*
  • Neoplasms / therapy*
  • Optical Imaging / methods
  • Phototherapy / methods*
  • Xenograft Model Antitumor Assays

Substances

  • Disulfides
  • Molybdenum
  • molybdenum disulfide