Abstract
The new 6,6-spiroketal,sargassopenilline H (1), and known peneciraistin C (2) have been isolated from an EtOAc extract of the marine-derived fungus Penicillium lividumKMM 4663. The structure of the new metabolite was determined by HR ESIMS and 1D and 2D NMR spectroscopy. Sargassopenilline H (1) in non-cytotoxic concentration inhibited colony formation of RPMI-7951 and MDA-MB-231 cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Benzopyrans / chemistry*
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Benzopyrans / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Humans
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Molecular Structure
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Penicillium / chemistry*
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Spiro Compounds / chemistry*
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Spiro Compounds / pharmacology*
Substances
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Antineoplastic Agents
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Benzopyrans
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Spiro Compounds
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peneciraistin C
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sargassopenilline H