The autophagy-lysosomal system in subarachnoid haemorrhage

Abstract

The autophagy-lysosomal pathway is a self-catabolic process by which dysfunctional or unnecessary intracellular components are degraded by lysosomal enzymes. Proper function of this pathway is critical for maintaining cell homeostasis and survival. Subarachnoid haemorrhage (SAH) is one of the most devastating forms of stroke. Multiple pathogenic mechanisms, such as inflammation, apoptosis, and oxidative stress, are all responsible for brain injury and poor outcome after SAH. Most recently, accumulating evidence has demonstrated that the autophagy-lysosomal pathway plays a crucial role in the pathophysiological process after SAH. Appropriate activity of autophagy-lysosomal pathway acts as a pro-survival mechanism in SAH, while excessive self-digestion results in cell death after SAH. Consequently, in this review article, we will give an overview of the pathophysiological roles of autophagy-lysosomal pathway in the pathogenesis of SAH. And approaching the molecular mechanisms underlying this pathway in SAH pathology is anticipated, which may ultimately allow development of effective therapeutic strategies for SAH patients through regulating the autophagy-lysosomal machinery.

Keywords: autophagy; cell death; lysosome; neuroprotection; subarachnoid haemorrhage.