In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives

Mostafa M Ghorab; Mansour S Alsaid; Mohammed S Al-Dosari; Marwa G El-Gazzar; Ahmed H Arbab

doi:10.3390/molecules21040409

In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives

Molecules. 2016 Mar 25;21(4):409. doi: 10.3390/molecules21040409.

Authors

Mostafa M Ghorab^{1

2}, Mansour S Alsaid³, Mohammed S Al-Dosari⁴, Marwa G El-Gazzar⁵, Ahmed H Arbab⁶

Affiliations

¹ Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia. mmsghorab@yahoo.com.
² Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, Cairo 113701, Egypt. mmsghorab@yahoo.com.
³ Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia. msalsaid@ksu.edu.sa.
⁴ Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia. msdosari@yahoo.com.
⁵ Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, Cairo 113701, Egypt. marwagalalgazzar@yahoo.com.
⁶ Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia. arbabssn@gmail.com.

Abstract

A novel series of sulfonamide derivatives (14 compounds) bearing thiourea moieties were efficiently synthesized and evaluated for their possible in vitro anticancer activity against four human tumor cell lines. The results indicated that compound 6 was the most potent, showing effectiveness on all the tested cell lines. Compounds 7 and 10 also showed promising results.

Keywords: anticancer activity; sulfonamides; synthesis; thioureido.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / administration & dosage
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Cell Line, Tumor
Cell Proliferation / drug effects*
Humans
Sulfonamides / administration & dosage
Sulfonamides / chemical synthesis
Sulfonamides / chemistry*
Thiourea / chemistry

Substances

Antineoplastic Agents
Sulfonamides
Thiourea