Effect of Repeated 1-h Episodes of Immobilization Stress on Activity of Glucocorticoid Metabolism Enzymes in the Liver

V E Tseilikman; D A Kozochkin; A I Sinitskii; O B Tseylikman; M S Lapshin; O V Kuzina; M V Komel'kova; I B Telesheva

doi:10.1007/s10517-016-3230-8

Effect of Repeated 1-h Episodes of Immobilization Stress on Activity of Glucocorticoid Metabolism Enzymes in the Liver

Bull Exp Biol Med. 2016 Mar;160(5):614-6. doi: 10.1007/s10517-016-3230-8. Epub 2016 Mar 29.

Authors

V E Tseilikman¹, D A Kozochkin², A I Sinitskii², O B Tseylikman³, M S Lapshin³, O V Kuzina², M V Komel'kova², I B Telesheva²

Affiliations

¹ South-Ural State Medical University, the Ministry of health of the Russian Federation, Chelyabinsk, Russia. vadimed@yandex.ru.
² South-Ural State Medical University, the Ministry of health of the Russian Federation, Chelyabinsk, Russia.
³ South-Ural State University (National Research University), Chelyabinsk, Russia.

PMID: 27021104
DOI: 10.1007/s10517-016-3230-8

Abstract

Differences in corticosterone level associated with different activity of glucocorticoid-oxidizing enzymes in the liver were revealed in rats exposed to stress. Pro-inflammatory changes in the liver were associated with enhanced CYP3A-dependent monooxygenation.

Keywords: 11β-hydroxysteroid dehydrogenase-2, CYP3A; corticosterone; stress.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Corticosterone / metabolism*
Cytochrome P-450 CYP3A / metabolism*
Glucocorticoids / metabolism*
Immobilization
Interleukin-1beta / blood
Interleukin-6 / blood
Lipid Metabolism
Liver / enzymology*
Liver / metabolism*
Male
Oxidation-Reduction
Rats
Rats, Wistar
Stress, Psychological / metabolism*

Substances

Glucocorticoids
IL1B protein, rat
Interleukin-1beta
Interleukin-6
Cytochrome P-450 CYP3A
Corticosterone