Immunochemical Nature of Receptors of Pseudotuberculosis Diagnostic Bacteriophage

Bull Exp Biol Med. 2016 Mar;160(5):672-4. doi: 10.1007/s10517-016-3246-0. Epub 2016 Mar 29.

Abstract

The effect of treatment of Yersinia pseudotuberculosis cells with antibodies of various specificities on adhesiveness of pseudotuberculosis bacteriophage was analyzed by competitive inhibition technique. Bacteriophage adsorption to bacteria was sterically inhibited by monoclonal antibodies to protein epitopes of Y. pseudotuberculosis outer membrane. These results suggest that receptors of pseudotuberculosis diagnostic bacteriophage are localized on the LPS core of microbial cell.

Keywords: Y. pseudotuberculosis; bacteriophage; monoclonal antibody; receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal / immunology*
  • Bacteriophages / metabolism*
  • Lipopolysaccharides / metabolism*
  • Receptors, Virus / immunology*
  • Virus Attachment*
  • Yersinia pseudotuberculosis / metabolism*
  • Yersinia pseudotuberculosis Infections / virology

Substances

  • Antibodies, Monoclonal
  • Lipopolysaccharides
  • Receptors, Virus