Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

Markus Müllner; Dharmini Mehta; Cameron J Nowell; Christopher J H Porter

doi:10.1039/c6cc00447d

Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

Chem Commun (Camb). 2016 Jul 12;52(58):9121-4. doi: 10.1039/c6cc00447d.

Authors

Markus Müllner¹, Dharmini Mehta², Cameron J Nowell³, Christopher J H Porter²

Affiliations

¹ Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, Sydney 2006, New South Wales, Australia. markus.muellner@sydney.edu.au.
² Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia and ARC Centre for Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.
³ Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.

PMID: 27020543
DOI: 10.1039/c6cc00447d

Abstract

The shape-persistent nature and conformation of cylindrical polymer brushes (CPBs) present opportunities to explore the properties of anisotropic (i.e. non spherical) nanomaterials in biological settings. This study shows that CPBs with lengths of up to 1 μm are able to passively target tumours via the enhanced permeation and retention (EPR) effect. Moreover, large CPBs with higher aspect ratios (ARs) were able to penetrate tumours with similar efficiencies to much smaller systems with lower ARs.

MeSH terms

Animals
Mice
Mice, Nude
Nanostructures / administration & dosage
Nanostructures / chemistry*
Neoplasms, Experimental / chemistry
Neoplasms, Experimental / metabolism
Particle Size
Polymers / administration & dosage
Polymers / chemistry*
Polymers / pharmacokinetics
Surface Properties
Tissue Distribution

Substances

Polymers