Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery

Xin Du; Xiaoyu Li; Lin Xiong; Xueji Zhang; Freddy Kleitz; Shi Zhang Qiao

doi:10.1016/j.biomaterials.2016.03.019

Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery

Biomaterials. 2016 Jun:91:90-127. doi: 10.1016/j.biomaterials.2016.03.019. Epub 2016 Mar 16.

Authors

Xin Du¹, Xiaoyu Li², Lin Xiong³, Xueji Zhang⁴, Freddy Kleitz⁵, Shi Zhang Qiao⁶

Affiliations

¹ Research Center for Bioengineering and Sensing Technology, University of Science & Technology Beijing, Beijing 100083, China; School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia.
² Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
³ School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia.
⁴ Research Center for Bioengineering and Sensing Technology, University of Science & Technology Beijing, Beijing 100083, China. Electronic address: zhangxueji@ustb.edu.cn.
⁵ Department of Chemistry and Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, Quebec City, QC G1V 0A6, Canada.
⁶ School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: s.qiao@adelaide.edu.au.

PMID: 27017579
DOI: 10.1016/j.biomaterials.2016.03.019

Abstract

Mesoporous silica material with organo-bridged silsesquioxane frameworks is a kind of synergistic combination of inorganic silica, mesopores and organics, resulting in some novel or enhanced physicochemical and biocompatible properties compared with conventional mesoporous silica materials with pure Si-O composition. With the rapid development of nanotechnology, monodispersed nanoscale periodic mesoporous organosilica nanoparticles (PMO NPs) and organo-bridged mesoporous silica nanoparticles (MSNs) with various organic groups and structures have recently been synthesized from 100%, or less, bridged organosilica precursors, respectively. Since then, these materials have been employed as carrier platforms to construct bioimaging and/or therapeutic agent delivery nanosystems for nano-biomedical application, and they demonstrate some unique and/or enhanced properties and performances. This review article provides a comprehensive overview of the controlled synthesis of PMO NPs and organo-bridged MSNs, physicochemical and biocompatible properties, and their nano-biomedical application as bioimaging agent and/or therapeutic agent delivery system.

Keywords: Advanced nanocarriers; Biocompatible properties; Bioimaging; Mesoporous nanoparticles; PMOs; Therapeutic agent delivery.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Drug Carriers / chemistry*
Drug Delivery Systems / methods
Gene Transfer Techniques
Humans
Nanoparticles / chemistry*
Nanotechnology / methods*
Organosilicon Compounds / chemistry*
Porosity
Silicon Dioxide / chemistry*
Theranostic Nanomedicine / methods*

Substances

Drug Carriers
Organosilicon Compounds
Silicon Dioxide