p85α is an intrinsic regulator of human natural killer cell effector functions

J Allergy Clin Immunol. 2016 Aug;138(2):605-608.e3. doi: 10.1016/j.jaci.2016.01.026. Epub 2016 Mar 23.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Cell Degranulation
  • Class Ia Phosphatidylinositol 3-Kinase
  • Cytotoxicity, Immunologic
  • Humans
  • Hyper-IgM Immunodeficiency Syndrome / enzymology*
  • Hyper-IgM Immunodeficiency Syndrome / genetics
  • Hyper-IgM Immunodeficiency Syndrome / immunology*
  • Interferon-gamma / biosynthesis
  • K562 Cells
  • Killer Cells, Natural / enzymology*
  • Killer Cells, Natural / immunology*
  • Mutation
  • Phosphatidylinositol 3-Kinases / genetics
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Signal Transduction

Substances

  • Interferon-gamma
  • PIK3R1 protein, human
  • Class Ia Phosphatidylinositol 3-Kinase