Autoantibodies to Collagen XVII Are Present in Parkinson's Disease and Localize to Tyrosine-Hydroxylase Positive Neurons

J Invest Dermatol. 2016 Mar;136(3):721-723. doi: 10.1016/j.jid.2015.12.005. Epub 2015 Dec 14.

Authors

Kelly A N Messingham¹, Samantha Aust¹, Joseph Helfenberger¹, Krystal L Parker², Susan Schultz³, Julie McKillip¹, Nandakumar S Narayanan², Janet A Fairley⁴

Affiliations

¹ Department of Dermatology, University of Iowa, Iowa City, IA.
² Department of Neurology and Aging Mind and Brain Initiative, University of Iowa, Iowa City, IA.
³ Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA.
⁴ Department of Dermatology, University of Iowa, Iowa City, IA; Veterans Administration Medical Center, Iowa City, IA. Electronic address: janet-fairley@uiowa.edu.

No abstract available

Publication types

Comparative Study
Letter
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Autoantibodies / blood
Autoantibodies / immunology*
Autoantigens / immunology
Autoantigens / metabolism*
Biomarkers / blood
Case-Control Studies
Collagen Type XVII
Confidence Intervals
Female
Fluorescent Antibody Technique, Indirect
Humans
Male
Neurons / metabolism
Neurons / pathology
Non-Fibrillar Collagens / immunology
Non-Fibrillar Collagens / metabolism*
Parkinson Disease / blood
Parkinson Disease / immunology*
Parkinson Disease / physiopathology
Pemphigoid, Bullous / immunology
Pemphigoid, Bullous / physiopathology
Reference Values
Tyrosine 3-Monooxygenase / immunology
Tyrosine 3-Monooxygenase / metabolism*

Substances

Autoantibodies
Autoantigens
Biomarkers
Non-Fibrillar Collagens
Tyrosine 3-Monooxygenase

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