CASTORing New Light on Amino Acid Sensing

James E Hughes Hallett; Brendan D Manning

doi:10.1016/j.cell.2016.03.002

CASTORing New Light on Amino Acid Sensing

Cell. 2016 Mar 24;165(1):15-17. doi: 10.1016/j.cell.2016.03.002.

Authors

James E Hughes Hallett¹, Brendan D Manning²

Affiliations

¹ Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston MA, USA.
² Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston MA, USA. Electronic address: bmanning@hsph.harvard.edu.

PMID: 27015302
DOI: 10.1016/j.cell.2016.03.002

Abstract

The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.

Publication types

Comment

MeSH terms

Amino Acids / metabolism*
Light
Signal Transduction*

Substances

Amino Acids