UCH-L1 in DLBCL: marker or target?

Blood. 2016 Mar 24;127(12):1524-5. doi: 10.1182/blood-2016-01-689984.

Abstract

In this issue of Blood, Bedekovics et al have demonstrated that a multifunctional molecule of the ubiquitin system ubiquitin C-terminal hydrolase L1 (UCH-L1) is induced in diffuse large B-cell lymphomas (DLBCLs), and that levels of this molecule are higher in germinal center (GC) B-cell DLBCL (GCB-DLBCL) compared with activated B-cell DLBCL (ABC-DLBCL) and predict poor outcomes.

Publication types

  • Comment

MeSH terms

  • Animals
  • B-Lymphocytes / pathology*
  • Gene Expression Regulation, Neoplastic*
  • Germinal Center / pathology*
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / genetics*
  • Ubiquitin Thiolesterase / genetics*

Substances

  • Ubiquitin Thiolesterase