Genomic and Epigenomic Landscape in Meningioma

Wenya Linda Bi; Yu Mei; Pankaj K Agarwalla; Rameen Beroukhim; Ian F Dunn

doi:10.1016/j.nec.2015.11.009

Genomic and Epigenomic Landscape in Meningioma

Neurosurg Clin N Am. 2016 Apr;27(2):167-79. doi: 10.1016/j.nec.2015.11.009.

Authors

Wenya Linda Bi¹, Yu Mei², Pankaj K Agarwalla³, Rameen Beroukhim³, Ian F Dunn⁴

Affiliations

¹ Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 15 Francis Street, PBB-3, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
² Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 15 Francis Street, PBB-3, Boston, MA, USA.
³ Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
⁴ Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 15 Francis Street, PBB-3, Boston, MA, USA. Electronic address: idunn@partners.org.

PMID: 27012381
DOI: 10.1016/j.nec.2015.11.009

Abstract

Meningiomas are the most common primary intracranial neoplasms in adults. Despite their prevalence, their biologic underpinnings remain incompletely described. The recent application of unbiased next-generation sequencing and epigenomic approaches has implicated a new array of candidate biomarkers and oncogenic drivers. These insights may serve to craft a molecular taxonomy for meningiomas and highlight putative therapeutic targets in an era of biology-informed precision medicine.

Keywords: Epigenetics; Genomics; Meningioma; Molecular taxonomy; Precision medicine.

Publication types

Review

MeSH terms

Animals
Chromosome Aberrations
DNA Methylation
Epigenesis, Genetic*
Humans
Meningeal Neoplasms / genetics*
Meningioma / genetics*
Mutation*