Abstract
Six long-chain peptaibols, 1 - 6, were identified from agar cultures of a marine-derived Trichoderma longibrachiatum Rifai strain (MMS151) isolated from blue mussels. The structure elucidation was carried out using electrospray ionization ion trap mass spectrometry (ESI-IT-MS) and GC/EI-MS. The long-chain peptaibols exhibited the general building scheme Ac-Aib-Ala-Aib-Ala-Aib-XXX-Gln-Aib-Vxx-Aib-Gly-XXX-Aib-Pro-Vxx-Aib-XXX-Gln-Gln-Pheol and were similar or identical to recurrent 20-residue peptaibols produced by Trichoderma spp. Three new sequences were identified and were called longibrachins A-0, A-II-a, and A-IV-b. The isolated peptaibols were assayed for cytotoxic, antibacterial, and antifungal activities, and acute toxicity on Dipteran larvae.
Keywords:
Long-chain peptaibols; Longibrachins A-0, A-II-a, and A-IV-b; Marine-derived fungi; Trichoderma longibrachiatum.
© 2016 Verlag Helvetica Chimica Acta AG, Zürich.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Bacteria / drug effects
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Biological Products / chemistry
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Biological Products / isolation & purification
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Biological Products / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Diptera / drug effects
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Diptera / embryology
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Drug Screening Assays, Antitumor
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Fungi / drug effects
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Microbial Sensitivity Tests
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Peptaibols / chemistry
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Peptaibols / isolation & purification
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Peptaibols / pharmacology*
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Trichoderma / chemistry*
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Antineoplastic Agents, Phytogenic
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Biological Products
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Peptaibols
Associated data
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GENBANK/DQ125467
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GENBANK/JQ653057