Abstract
By phosphorylating specific replication factors, cell cycle kinases ensure that eukaryotic DNA replication is initiated once and only once per mitotic cell division. New work in The EMBO Journal now reveals how DDK‐mediated phosphorylation of Mcm2‐7 helicase subunits is read out by Sld3, which provides further integration with CDK phosphorylation.
MeSH terms
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Cell Cycle Proteins / genetics*
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DNA Replication*
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Humans
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Protein Serine-Threonine Kinases / genetics
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Saccharomyces cerevisiae Proteins / genetics
Substances
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Cell Cycle Proteins
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Saccharomyces cerevisiae Proteins
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Protein Serine-Threonine Kinases