Vesicles as Vehicles for Virulence

Monica R Mugnier; F Nina Papavasiliou; Danae Schulz

doi:10.1016/j.pt.2016.03.001

Vesicles as Vehicles for Virulence

Trends Parasitol. 2016 Jun;32(6):435-436. doi: 10.1016/j.pt.2016.03.001. Epub 2016 Mar 20.

Authors

Monica R Mugnier¹, F Nina Papavasiliou², Danae Schulz³

Affiliations

¹ Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; The Rockefeller Graduate Program, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: mmugnier@rockefeller.edu.
² Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: papavasiliou@rockefeller.edu.
³ Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; Current address: Department of Biology, Harvey Mudd College, 301 Platt Bvd, Claremont, CA 91711, USA. Electronic address: dschulz@rockefeller.edu.

Abstract

Parasites have long been known to influence host responses to infection through the secretion of virulence factors. Extracellular vesicles are emerging as important mediators of these manipulations, and a new study by Szempruch et al. suggests they could play a crucial role in host responses to African trypanosome infections.

Publication types

Comment

MeSH terms

Animals
Host-Parasite Interactions / genetics
Host-Parasite Interactions / immunology*
Humans
Secretory Vesicles / immunology*
Trypanosoma brucei brucei / immunology
Trypanosomiasis, African / immunology*
Trypanosomiasis, African / parasitology*
Virulence Factors / genetics
Virulence Factors / immunology*

Substances

Virulence Factors

Grants and funding

R01 AI085973/AI/NIAID NIH HHS/United States