Spontaneous hypoglycaemia in a patient with Graves' disease

BMJ Case Rep. 2016 Mar 22:2016:bcr2016214801. doi: 10.1136/bcr-2016-214801.

Abstract

A 23-year-old man, on treatment for Graves' disease, presented to the emergency department, with 2 separate episodes of loss of consciousness. During the first episode, the initial serum glucose was 19 mg/mL, and 44 mg/dL during the second episode. The patient was non-diabetic, and had elevated blood insulin, C peptide and insulin antibody levels. His abdominal radiographic findings were normal. He was diagnosed with Hirata disease, and put on propylthiouracil as a replacement for carbimazole. Hypoglycaemia was managed with dextrose infusions and frequent meals. The patient's condition improved and he had no further episodes of hypoglycaemia during the follow-up period.

Publication types

  • Case Reports

MeSH terms

  • Blood Glucose / metabolism
  • Carbimazole / therapeutic use
  • Disease Management
  • Glucose / administration & dosage
  • Graves Disease / complications*
  • Graves Disease / drug therapy
  • Humans
  • Hypoglycemia / diagnosis*
  • Hypoglycemia / drug therapy
  • Hypoglycemia / etiology
  • Male
  • Propylthiouracil / therapeutic use
  • Young Adult

Substances

  • Blood Glucose
  • Propylthiouracil
  • Carbimazole
  • Glucose