Marine Metabolites Modulating CB Receptors and TRP Channels

Planta Med. 2016 Jun;82(9-10):761-6. doi: 10.1055/s-0042-101352. Epub 2016 Mar 22.

Abstract

Transient receptor potential channels and cannabinoid receptors are deputed to the regulation of sensory, homeostatic, and inflammatory events in the human organism. Therefore, their modulation promises to have relevant applications in important therapeutic areas such as inflammation, pain, and cancer. This review summarizes the contribution of marine research in this relatively young field, highlighting the potential of the chemodiversity carried by marine natural products in the discovery of new ligands.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthozoa / chemistry
  • Aquatic Organisms
  • Biological Products / pharmacology*
  • Cyanobacteria / chemistry
  • Fungi / chemistry
  • Humans
  • Porifera / chemistry
  • Receptors, Cannabinoid / drug effects*
  • Transient Receptor Potential Channels / drug effects*

Substances

  • Biological Products
  • Receptors, Cannabinoid
  • Transient Receptor Potential Channels