Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer

Mohammad Mahdi Hasani-Sadrabadi; Shahrouz Taranejoo; Erfan Dashtimoghadam; Ghasem Bahlakeh; Fatemeh Sadat Majedi; Jules John VanDersarl; Mohsen Janmaleki; Fatemeh Sharifi; Arnaud Bertsch; Kerry Hourigan; Lobat Tayebi; Philippe Renaud; Karl I Jacob

doi:10.1002/adma.201502697

Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer

Adv Mater. 2016 Jun;28(21):4134-41. doi: 10.1002/adma.201502697. Epub 2016 Mar 22.

Authors

Affiliations

¹ Parker H. Petit Institute for Bioengineering and Bioscience, G. W. Woodruff School of Mechanical Engineering and School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0295, USA.
² Department of Chemical Engineering, Monash University, Melbourne, VIC, 3168, Australia.
³ Laboratory for Biomedical Engineering/Fluids, Laboratory for Aeronautical and Industrial Research, Department of Mechanical and Aerospace Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, 3168, Australia.
⁴ Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI, 53201, USA.
⁵ Department of Chemical Engineering, Amirkabir University of Technology, Tehran, 49417-15344, Iran.
⁶ Department of Bioengineering, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
⁷ Laboratoire de Microsystemes (LMIS4), Institute of Microengineering and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
⁸ Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17444, Iran.
⁹ Department of Mechanical Engineering, Sharif University of Technology, Tehran, 11365-11155, Iran.
¹⁰ Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Palo Alto, CA, 94304, USA.

PMID: 27001745
DOI: 10.1002/adma.201502697

Abstract

A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.

Keywords: cancer therapy; core-shell nanoparticles; drug delivery; microfluidics platform; stimuli-responsive release.

MeSH terms

Colonic Neoplasms
Drug Carriers
Drug Delivery Systems
Drug Liberation
Humans
Hydrogen-Ion Concentration
Microfluidics*
Nanoparticles

Substances

Drug Carriers