Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties

Takuya Chiba; Yukihiro Asami; Takuya Suga; Yoshihiro Watanabe; Takayuki Nagai; Fumitaka Momose; Kenichi Nonaka; Masato Iwatsuki; Haruki Yamada; Satoshi Ōmura; Kazuro Shiomi

doi:10.1080/09168451.2016.1162084

Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties

Biosci Biotechnol Biochem. 2017 Jan;81(1):59-62. doi: 10.1080/09168451.2016.1162084. Epub 2016 Mar 21.

Authors

Takuya Chiba¹, Yukihiro Asami^{1

2}, Takuya Suga¹, Yoshihiro Watanabe¹, Takayuki Nagai^{1

2}, Fumitaka Momose^{1

2}, Kenichi Nonaka^{1

2}, Masato Iwatsuki^{1

2}, Haruki Yamada^{1

2}, Satoshi Ōmura², Kazuro Shiomi^{1

2}

Affiliations

¹ a Graduate School of Infection Control Sciences , Kitasato University , Tokyo , Japan.
² b Kitasato Institute for Life Sciences , Kitasato University , Tokyo , Japan.

PMID: 26999706
DOI: 10.1080/09168451.2016.1162084

Abstract

In the course of screening for new anti-influenza virus antibiotics, we isolated herquline A from a culture broth of the fungus, Penicillium herquei FKI-7215. Herquline A inhibited replication of influenza virus A/PR/8/34 strain in a dose-dependent manner without exhibiting cytotoxicity against several human cell lines. It did not inhibit the viral neuraminidase.

Keywords: A/PR/8/34 strain; Penicillium herquei; herquline A; influenza virus.

MeSH terms

Alkaloids / biosynthesis*
Alkaloids / chemistry
Alkaloids / pharmacology*
Alkaloids / toxicity
Antiviral Agents / chemistry
Antiviral Agents / metabolism*
Antiviral Agents / pharmacology*
Antiviral Agents / toxicity
Cell Line
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Humans
Orthomyxoviridae / drug effects*
Orthomyxoviridae / physiology
Penicillium / metabolism*
Virus Replication / drug effects

Substances

Alkaloids
Antiviral Agents
herqueline