Abstract
Studying the effect of a magnetic field on oligonucleotide DNA can provide a novel DNA manipulation technique for potential application in bioengineering and medicine. In this work, the optical and electrochemical response of a 100 bases oligonucleotides DNA, cytosine-guanine (CG100), is investigated via exposure to different magnetic fields (250, 500, 750, and 1000 mT). As a result of the optical response of CG100 to the magnetic field, the ultra-violet-visible spectrum indicated a slight variation in the band gap of CG100 of about 0.3 eV. Raman spectroscopy showed a significant deviation in hydrogen and phosphate bonds' vibration after exposure to the magnetic field. Oligonucleotide DNA mobility was investigated in the external electric field using the gel electrophoresis technique, which revealed a small decrease in the migration of CG100 after exposure to the magnetic field.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA / isolation & purification*
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Electrophoresis / methods*
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Magnetics*
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Spectrophotometry, Ultraviolet / methods*
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Spectrum Analysis, Raman / methods*
Grants and funding
This research was supported by IPPP-BKP grant BK003-2015, UM/MOHE High Impact Research Grant allocation of F000006-21001, HIR grants (J-21002-73823 and UM.C/HIR/MOHE/SC/06) and FRGS grant (FP004/2013A). S. M. Banihashemian conducted the experiments and took the measurements with advice and consultation from all authors and BK003-2015 is her BKP grant. Set up preparation, picture and redraw of schematic also prepared by Seyedeh Maryam. Saadah Abdul Rahman, Vengadesh Periasamand and Goh Boon Tong helped to prepare the designed set up and all authors contributed to writing, editing and reviewing the paper that UM/MOHE High Impact Research Grant allocation of F000006-21001, HIR grants (J-21002-73823 and UM.C/HIR/MOHE/SC/06) and FRGS grant (FP004/2013A) are their grant respectively.