Two new lignans from the aerial part of Vitex negundo

Xiu-Fang Nie; Li-Li Yu; Yuan Tao; Jian Huang; Li-Qin Ding; Xin-Chi Feng; Miao-Miao Jiang; Lin Zheng; Li-Xia Chen; Feng Qiu

doi:10.1080/10286020.2016.1142975

Two new lignans from the aerial part of Vitex negundo

J Asian Nat Prod Res. 2016 Jul;18(7):656-61. doi: 10.1080/10286020.2016.1142975. Epub 2016 Mar 21.

Authors

Affiliations

¹ a Key Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
² b Tianjin State Key Laboratory of Modern Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin 300193 , China.

PMID: 26999269
DOI: 10.1080/10286020.2016.1142975

Abstract

A new phenyldihydronaphthalene-type lignan, (3R,4S)-6-hydroxy-4-(4-hydroxy- 3-methoxyphenyl)-5,7-dimethoxy-3,4-dihydro-2-naphthaldehyde-3a-O-β-d-glucopyranoside (1), and a new phenylnaphthalene-type lignan, 6,7,4'-trihydroxy-3'-methoxy-2,3- cycloligna-1,4-dien-2a,3a-olide (2), along with 10-known lignan derivatives (3-12) were isolated from the aerial part of Vitex negundo var. heterophylla. Their structures were established by comprehensive 1D- and 2D-NMR spectroscopic analyses.

Keywords: Verbenaceae; Vitex negundo var. heterophylla; lignan; vitecannaside; vitexdoin.

MeSH terms

Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification*
Glucosides / chemistry
Glucosides / isolation & purification*
Lignans / chemistry
Lignans / isolation & purification*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Components, Aerial / chemistry*
Vitex / chemistry*

Substances

(3R,4S)-6-hydroxy-4-(4-hydroxy- 3-methoxyphenyl)-5,7-dimethoxy-3,4-dihydro-2-naphthaldehyde-3alpha-O-beta-D-glucopyranoside
Drugs, Chinese Herbal
Glucosides
Lignans