Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

Nat Genet. 2016 May;48(5):519-27. doi: 10.1038/ng.3531. Epub 2016 Mar 21.

Abstract

Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alters the response of NOD beta cells to unfolded protein stress, enhancing the apoptotic and senescent fates. The same transcriptional relationships were observed in human islets, demonstrating the role of beta cell fragility in genetic predisposition to diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Cellular Senescence
  • DNA-Binding Proteins / genetics
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 1 / pathology
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / pathology
  • Diet
  • Female
  • Gene Expression Regulation
  • Genetic Predisposition to Disease*
  • Humans
  • Insulin-Secreting Cells / pathology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred NOD
  • Mice, Transgenic
  • Protein Folding
  • Repressor Proteins / genetics
  • Sex Factors
  • Stress, Physiological
  • Trans-Activators / genetics

Substances

  • DNA-Binding Proteins
  • Glis3 protein, mouse
  • Repressor Proteins
  • Trans-Activators
  • XRCC4 protein, mouse