Abstract
The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antimetabolites, Antineoplastic / administration & dosage*
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Antimetabolites, Antineoplastic / chemistry
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Antimetabolites, Antineoplastic / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Delayed-Action Preparations / chemistry*
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Dipeptides / chemistry*
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Fluorouracil / administration & dosage*
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Fluorouracil / chemistry
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Fluorouracil / pharmacology
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Humans
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Hydrogels / chemistry*
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Neoplasms / drug therapy
Substances
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Antimetabolites, Antineoplastic
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Delayed-Action Preparations
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Dipeptides
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Hydrogels
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lysyllysine
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Fluorouracil