Bayesian non-parametric inference for stochastic epidemic models using Gaussian Processes

Biostatistics. 2016 Oct;17(4):619-33. doi: 10.1093/biostatistics/kxw011. Epub 2016 Mar 18.

Abstract

This paper considers novel Bayesian non-parametric methods for stochastic epidemic models. Many standard modeling and data analysis methods use underlying assumptions (e.g. concerning the rate at which new cases of disease will occur) which are rarely challenged or tested in practice. To relax these assumptions, we develop a Bayesian non-parametric approach using Gaussian Processes, specifically to estimate the infection process. The methods are illustrated with both simulated and real data sets, the former illustrating that the methods can recover the true infection process quite well in practice, and the latter illustrating that the methods can be successfully applied in different settings.

Keywords: Bayesian non-parametrics; Epidemic model; Gaussian process; SIR model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bayes Theorem*
  • Epidemics*
  • Humans
  • Models, Theoretical*
  • Normal Distribution*
  • Stochastic Processes*