An Outbreak of Bartonella bacilliformis in an Endemic Andean Community

PLoS One. 2016 Mar 18;11(3):e0150525. doi: 10.1371/journal.pone.0150525. eCollection 2016.

Abstract

Background: Bartonellosis affects small Andean communities in Peru, Colombia and Ecuador. Research in this area has been limited.

Methods: Retrospective review of 191 cases of bartonellosis managed in Caraz District Hospital, Peru, during the last outbreak (2003).

Results: The majority of cases (65%) were 14 years old and younger. There was a peak in acute cases after the rainy season; chronic cases presented more constantly throughout the year. The sensitivity of blood smear against blood culture in acute disease was 25%. The most commonly used treatment for chronic disease was rifampicin; chloramphenicol was used to treat most acute cases. Complications arose in 6.8% and there were no deaths.

Conclusions: Diagnostic and treatment algorithms for acute and chronic bartonellosis have been developed without a strong evidence base. Preparation of ready-to-go operational research protocols for future outbreaks would strengthen the evidence base for diagnostic and treatment strategies and enhance opportunities for control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Algorithms*
  • Bartonella Infections / diagnosis
  • Bartonella Infections / drug therapy
  • Bartonella Infections / epidemiology
  • Bartonella Infections / pathology
  • Bartonella bacilliformis*
  • Child
  • Child, Preschool
  • Chloramphenicol / administration & dosage*
  • Chronic Disease
  • Disease Outbreaks*
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Peru / epidemiology
  • Rifampin / administration & dosage*

Substances

  • Chloramphenicol
  • Rifampin