Treg subsets in inflammatory bowel disease and colorectal carcinoma: Characteristics, role, and therapeutic targets

J Gastroenterol Hepatol. 2016 Aug;31(8):1393-404. doi: 10.1111/jgh.13342.

Abstract

T regulatory cells (Tregs) play an important role in the regulation of autoimmunity, autoinflammation, allergic diseases, infection, and the tumor environment. Different subsets are characterized that use a number of regulatory mechanisms. Tregs can influence the progression of inflammatory bowel disease and the development of colorectal cancer. Knowledge of Tregs and their regulatory mechanisms can provide new targets for therapeutic intervention.

Keywords: CRC; FOXP3; IBD; Tr1; Treg; therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Biomarkers, Tumor / metabolism
  • Carcinoma / diagnosis
  • Carcinoma / immunology*
  • Carcinoma / metabolism
  • Carcinoma / therapy
  • Colorectal Neoplasms / diagnosis
  • Colorectal Neoplasms / immunology*
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / therapy
  • Cytokines / metabolism
  • Humans
  • Immunotherapy / methods
  • Inflammation Mediators / metabolism
  • Inflammatory Bowel Diseases / diagnosis
  • Inflammatory Bowel Diseases / immunology*
  • Inflammatory Bowel Diseases / metabolism
  • Inflammatory Bowel Diseases / therapy
  • Lymphocytes, Tumor-Infiltrating / drug effects
  • Lymphocytes, Tumor-Infiltrating / immunology*
  • Lymphocytes, Tumor-Infiltrating / metabolism
  • Molecular Targeted Therapy / methods
  • Phenotype
  • Signal Transduction
  • T-Lymphocytes, Regulatory / drug effects
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / metabolism

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Cytokines
  • Inflammation Mediators