Abstract
T regulatory cells (Tregs) play an important role in the regulation of autoimmunity, autoinflammation, allergic diseases, infection, and the tumor environment. Different subsets are characterized that use a number of regulatory mechanisms. Tregs can influence the progression of inflammatory bowel disease and the development of colorectal cancer. Knowledge of Tregs and their regulatory mechanisms can provide new targets for therapeutic intervention.
Keywords:
CRC; FOXP3; IBD; Tr1; Treg; therapy.
© 2016 The Authors Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
MeSH terms
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Animals
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Anti-Inflammatory Agents / therapeutic use
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Antineoplastic Agents / therapeutic use
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Biomarkers, Tumor / metabolism
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Carcinoma / diagnosis
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Carcinoma / immunology*
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Carcinoma / metabolism
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Carcinoma / therapy
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Colorectal Neoplasms / diagnosis
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Colorectal Neoplasms / immunology*
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Colorectal Neoplasms / metabolism
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Colorectal Neoplasms / therapy
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Cytokines / metabolism
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Humans
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Immunotherapy / methods
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Inflammation Mediators / metabolism
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Inflammatory Bowel Diseases / diagnosis
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Inflammatory Bowel Diseases / immunology*
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Inflammatory Bowel Diseases / metabolism
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Inflammatory Bowel Diseases / therapy
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Lymphocytes, Tumor-Infiltrating / drug effects
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Lymphocytes, Tumor-Infiltrating / immunology*
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Lymphocytes, Tumor-Infiltrating / metabolism
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Molecular Targeted Therapy / methods
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Phenotype
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Signal Transduction
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T-Lymphocytes, Regulatory / drug effects
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / metabolism
Substances
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Biomarkers, Tumor
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Cytokines
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Inflammation Mediators