RECIST Applied to Realistic Tumor Models

Zachary H Levine; Benjamin R Galloway; Adele P Peskin

doi:10.6028/jres.116.013

RECIST Applied to Realistic Tumor Models

J Res Natl Inst Stand Technol. 2011 Jun 1;116(3):685-8. doi: 10.6028/jres.116.013. Print 2011 May-Jun.

Authors

Zachary H Levine¹, Benjamin R Galloway¹, Adele P Peskin²

Affiliations

¹ Optical Technology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899-8441.
² Applied and Computational Mathematics Division, National Institute of Standards and Technology, Boulder, CO 80305-3328.

Abstract

RECIST (Response Evaluation Criteria in Solid Tumors) is a linear measure intended to predict tumor size in medical computed tomography (CT). In this work, using purely geometrical considerations, we estimate how well RECIST can predict the volume of randomly-oriented tumor models, each composed of the union of ellipsoids. The principal conclusion is that RECIST is likely to work less well for realistic tumors than for ellipsoids.

Keywords: RECIST; tumor size; volumetric measurement; x-ray imaging.