Diversity of Neural Precursors in the Adult Mammalian Brain

Michael A Bonaguidi; Ryan P Stadel; Daniel A Berg; Jiaqi Sun; Guo-li Ming; Hongjun Song

doi:10.1101/cshperspect.a018838

Diversity of Neural Precursors in the Adult Mammalian Brain

Cold Spring Harb Perspect Biol. 2016 Apr 1;8(4):a018838. doi: 10.1101/cshperspect.a018838.

Authors

Michael A Bonaguidi¹, Ryan P Stadel², Daniel A Berg³, Jiaqi Sun⁴, Guo-li Ming⁵, Hongjun Song⁶

Affiliations

¹ Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685.
² Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Human Genetics Predoctoral Program, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
³ Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
⁴ Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 School of Life Sciences, Tsinghua University, Beijing 100084, China.
⁵ Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
⁶ Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685 Human Genetics Predoctoral Program, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Abstract

Aided by advances in technology, recent studies of neural precursor identity and regulation have revealed various cell types as contributors to ongoing cell genesis in the adult mammalian brain. Here, we use stem-cell biology as a framework to highlight the diversity of adult neural precursor populations and emphasize their hierarchy, organization, and plasticity under physiological and pathological conditions.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Brain / cytology*
Cell Differentiation
Cell Lineage
Dentate Gyrus / cytology
Humans
Mammals / anatomy & histology*
Mammals / growth & development
Mice
Models, Biological
Neural Stem Cells / cytology*
Neural Stem Cells / physiology
Neurogenesis*
Rats

Abstract

Publication types

MeSH terms

Grants and funding