The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles

Genome Med. 2016 Mar 17;8(1):29. doi: 10.1186/s13073-016-0284-1.

Abstract

miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for the development of future miRNA-related therapies.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs / genetics*
  • Multigene Family*
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Tumor Microenvironment / genetics*

Substances

  • MIRN143 microRNA, human
  • MIRN145 microRNA, human
  • MicroRNAs