Organization of lipids in fiber-cell plasma membranes of the eye lens

Witold K Subczynski; Laxman Mainali; Marija Raguz; William J O'Brien

doi:10.1016/j.exer.2016.03.004

Organization of lipids in fiber-cell plasma membranes of the eye lens

Exp Eye Res. 2017 Mar:156:79-86. doi: 10.1016/j.exer.2016.03.004. Epub 2016 Mar 14.

Authors

Witold K Subczynski¹, Laxman Mainali², Marija Raguz³, William J O'Brien⁴

Affiliations

¹ Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address: subczyn@mcw.edu.
² Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
³ Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Department of Medical Physics and Biophysics, School of Medicine, University of Split, Split, Croatia.
⁴ Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Abstract

The plasma membrane together with the cytoskeleton forms the only supramolecular structure of the matured fiber cell which accounts for mostly all fiber cell lipids. The purpose of this review is to inform researchers about the importance of the lipid bilayer portion of the lens fiber cell plasma membranes in the maintaining lens homeostasis, and thus protecting against cataract development.

Keywords: Cholesterol; Cholesterol bilayer domain; Cholesterol crystals; Membrane domains; Oxygen permeation; Spin labeling.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Animals
Cell Membrane / metabolism*
Cholesterol / metabolism
Humans
Hydrophobic and Hydrophilic Interactions
Lens, Crystalline / metabolism*
Lipid Bilayers / metabolism
Membrane Fluidity
Membrane Lipids / metabolism
Oxygen / metabolism
Phospholipids / metabolism

Substances

Lipid Bilayers
Membrane Lipids
Phospholipids
Cholesterol
Oxygen

Abstract

Publication types

MeSH terms

Substances

Grants and funding