Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin

T Balligand; Y Achouri; C Pecquet; I Chachoua; H Nivarthi; C Marty; W Vainchenker; I Plo; R Kralovics; S N Constantinescu

doi:10.1038/leu.2016.47

Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin

Leukemia. 2016 Aug;30(8):1775-8. doi: 10.1038/leu.2016.47. Epub 2016 Feb 29.

Authors

T Balligand^{1

2}, Y Achouri³, C Pecquet^{1

2}, I Chachoua^{1

2}, H Nivarthi⁴, C Marty^{5

6

7}, W Vainchenker^{5

6

7}, I Plo^{5

6

7}, R Kralovics⁴, S N Constantinescu^{1

2}

Affiliations

¹ Ludwig Institute for Cancer Research Brussels, Brussels, Belgium.
² SIGN Pole, de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
³ LPAD Pole, de Duve Institute, Université catholique de Louvain, Brussels, Belgium.
⁴ Genetics of Hematological Disorders, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
⁵ INSERM, UMR1170, Villejuif, France.
⁶ Paris-Saclay, UMR1170, Villejuif, France.
⁷ Gustave Roussy, UMR1170, Villejuif, France.

PMID: 26987905
DOI: 10.1038/leu.2016.47

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calreticulin / genetics*
Cell Transformation, Neoplastic / genetics
Frameshift Mutation
Humans
Janus Kinase 2 / metabolism*
Mice
Receptors, Thrombopoietin / metabolism*
STAT5 Transcription Factor / metabolism*
Signal Transduction* / physiology

Substances

Calreticulin
Mpl protein, mouse
Receptors, Thrombopoietin
STAT5 Transcription Factor
Jak2 protein, mouse
Janus Kinase 2