Peptide based hydrogels for cancer drug release: modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating d-amino acid residue(s)

Chem Commun (Camb). 2016 Apr 11;52(28):5045-8. doi: 10.1039/c6cc01744d. Epub 2016 Mar 18.

Abstract

Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating d-amino acid residues, indicating their potential use for drug delivery in the future.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Antineoplastic Agents / administration & dosage*
  • Cell Survival
  • Drug Carriers / chemistry
  • Drug Delivery Systems*
  • Drug Liberation / drug effects*
  • Humans
  • Hydrogels / chemical synthesis
  • Hydrogels / chemistry*
  • MCF-7 Cells
  • Molecular Structure
  • Neoplasms / drug therapy
  • Peptides / chemistry*
  • Proteolysis*

Substances

  • Amino Acids
  • Antineoplastic Agents
  • Drug Carriers
  • Hydrogels
  • Peptides