Abstract
Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating d-amino acid residues, indicating their potential use for drug delivery in the future.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry*
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Antineoplastic Agents / administration & dosage*
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Cell Survival
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Drug Carriers / chemistry
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Drug Delivery Systems*
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Drug Liberation / drug effects*
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Humans
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Hydrogels / chemical synthesis
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Hydrogels / chemistry*
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MCF-7 Cells
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Molecular Structure
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Neoplasms / drug therapy
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Peptides / chemistry*
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Proteolysis*
Substances
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Amino Acids
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Antineoplastic Agents
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Drug Carriers
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Hydrogels
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Peptides