Abstract
Recently, a new paramyxovirus closely related to human mumps virus (MuV) was detected in bats. We generated recombinant MuVs carrying either or both of the fusion and hemagglutinin-neuraminidase bat virus glycoproteins. These viruses showed replication kinetics similar to human MuV in cultured cells and were neutralized efficiently by serum from healthy humans.
Keywords:
African bat mumps virus; Chimeric virus; bat virus; mumps virus; neutralization; viruses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Animals
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Antibodies, Viral / blood*
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Cell Line
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Chiroptera
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Chlorocebus aethiops
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Cricetulus
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Democratic Republic of the Congo / epidemiology
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Female
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Gene Expression
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HN Protein / genetics
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HN Protein / immunology
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Host Specificity
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Humans
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Immune Sera / chemistry
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Immune Sera / pharmacology
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Japan / epidemiology
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Male
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Middle Aged
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Mumps / epidemiology
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Mumps / immunology*
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Mumps / veterinary*
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Mumps / virology
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Mumps virus / genetics*
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Mumps virus / growth & development
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Mumps virus / isolation & purification
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Neutralization Tests
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Reassortant Viruses / genetics
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Reassortant Viruses / immunology*
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Vero Cells
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Viral Fusion Proteins / antagonists & inhibitors
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Viral Fusion Proteins / genetics
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Viral Fusion Proteins / immunology*
Substances
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Antibodies, Viral
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HN Protein
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Immune Sera
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Viral Fusion Proteins